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logic examination shows no abnormality except in a few patients in whom trigeminal neuralgia is symptomatic of some underlying lesion, such as multiple sclerosis or a brainstem neoplasm, in which case the finding will depend on the nature and site of the lesion Similarly, CT scans and radiologic contrast studies are normal in patients with classic trigeminal neuralgia In a young patient presenting with trigeminal neuralgia, multiple sclerosis must be suspected even if there are no other neurologic signs In such circumstances, findings on evoked potential testing and examination of cerebrospinal fluid may be corroborative When the facial pain is due to a posterior fossa tumor, CT scanning and MRI generally reveal the lesion

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The drugs most helpful for treatment are oxcarbazepine (although not approved by the US Food and Drug Administration [FDA] for this indication) or carbamazepine, with monitoring by serial blood counts and liver function tests If these medications are ineffective or cannot be tolerated, phenytoin should be tried (Doses and side effects of these drugs are shown in Table 24 3) Baclofen (10 20 mg three or four times daily) may also be helpful, either alone or in combination with one of these other agents Gabapentin may also relieve pain, especially in patients who do not respond to conventional medical therapy and those with multiple sclerosis Depending on response and tolerance, up to 2400 mg/d is given in divided doses In the past, alcohol injection of the affected nerve, rhizotomy, or tractotomy was recommended if pharmacologic treatment was unsuccessful More recently, however, posterior fossa exploration has frequently revealed some structural cause for the neuralgia (despite normal findings on CT scans, MRI, or arteriograms), such as an anomalous artery or vein impinging on the trigeminal nerve root In such cases, simple decompression and separation of the anomalous vessel from the nerve root produce lasting relief of symptoms In elderly patients with a limited life expectancy, radiofrequency rhizotomy is sometimes preferred because it is easy to perform, has few complications, and provides symptomatic relief for a period of time Gamma radiosurgery to the trigeminal root is another noninvasive approach that appears to be successful in 80% of patients, with essentially no side effects other than facial paresthesias in a few instances Surgical exploration generally reveals no abnormality and is inappropriate in patients with trigeminal neuralgia due to multiple sclerosis

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Liu JK et al Treatment of trigeminal neuralgia Neurosurg Clin North Am 2004 Jul;15(3):319 34 [PMID: 15246340] Rozen TD Trigeminal neuralgia and glossopharyngeal neuralgia Neurol Clin 2004 Feb;22(1):185 206 [PMID: 15062534]

Brief episodes of stabbing facial pain Pain is in the territory of the second and third division of the trigeminal nerve Pain exacerbated by touch

Trigeminal neuralgia ( tic douloureux ) is most common in middle and later life It affects women more frequently than men

Momentary episodes of sudden lancinating facial pain occur and commonly arise near one side of the mouth and shoot toward the ear, eye, or nostril on that side The pain may be triggered or precipitated by such factors as touch, movement, drafts, and eating Indeed, in order to lessen the likelihood of triggering further attacks, many patients try to hold the face still while talking Spontaneous remissions for several months or longer may occur As the disorder progresses, however, the episodes of pain become more frequent, remissions become shorter and less common, and a dull ache may persist between the episodes of stabbing pain Symptoms remain confined to the distribution of the trigeminal nerve (usually the second or third division) on one side only

Facial pain without the typical features of trigeminal neuralgia is generally a constant, often burning pain that may have a restricted distribution at its onset but soon spreads to the rest of the face on the affected side and sometimes involves the other side, the neck, or the back of the head as well The disorder is especially common in middle-aged women, many

The characteristic features of the pain in trigeminal neuralgia usually distinguish it from other causes of facial pain Neuro-

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of them depressed, but it is not clear whether depression is the cause of or a reaction to the pain Simple analgesics should be given a trial, as should tricyclic antidepressants, carbamazepine, oxcarbazepine, and phenytoin; the response is often disappointing Opioid analgesics pose a danger of addiction in patients with this disorder Attempts at surgical treatment are not indicated

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